RNAi Controls
Genscript Corporation CD3ECD3D hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation Her3/ErbB3 hFc Chimera Human
Her3 also called ErbB3 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors Her3 is expressed in keratinocytes melanocytes skeletal muscle cells embryonic myoblasts and Schwann cells Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG)
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
Genscript Corporation CD300LF hFc Chimera Human
Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly CD300lf as a proteinaceous receptor for MNoV Interestingly its paralogue CD300ld was also sufficient for MNoV infection in vitro CD300lf is essential for both oral and parenteral MNoV infection and to elicit anti-MNoV humoral responses in vivo human CD300lf (huCD300lf) is not essential for HNoV infection nor does huCD300lf inhibit binding of HNoV virus-like particles to glycans
Genscript Corporation CD37 hFc Chimera Human
CD37 is a tetraspanin expressed prominently on the surface of B cells It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia Currently several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical trials Given the unique role of CD37 in the biology of B cells it seems that CD37 constitutes more than a docking point for monoclonal antibodies and targeting this molecule may provide additional benefit to relapsed or refractory patients
Genscript Corporation CD27/TNFRSF7 hFc Chimera Cyno
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation SLAMF7/CRACC/CD319 hFc Chimera
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Genscript Corporation CD96/TACTILE mFc Chimera Huma
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
Genscript Corporation CD52 mFc Chimera Human
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation CD30/TNFRSF8 hFc Chimera Huma
The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153 TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions CD30 expression is upregulated in various hematological malignancies including Reed-Sternberg cells in Hodgkin s disease (HD) anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin s lymphomas (NHLs)
Genscript Corporation NKG2D/CD314 hFc Chimera Flag
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands Human NKG2D is expressed on CD8 alpha beta T cells gamma T cells NK cells and NKT cells
Genscript Corporation CD27/TNFRSF7 hFc Chimera Huma
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation SIRP Fc Chimera Human
Signal regulatory protein alpha (SIRP designated CD172a) is also known as CD172 antigen-like family member A (CD172a) also called SHPS-1 (SHP substrate 1) and previously MyD-1 (Myeloid/Dendritic-1) which is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily SIRP is Ubiquitous and highly expressed in brain SIRPA/CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6 PTPN11 and other binding partners from the cytosol to the plasma membrane SIRPA/SHPS-1 supports adhesion of cerebellar neurons neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function by similarity SIRP recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production
Genscript Corporation CD160 hFc Chimera Human
CD160 (also Natural killer cell receptor BY55) is a 27 30 kDa member of the Ig superfamily In human it is expressed principally on nonmyeloid hematopoietic cells CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation Exists as a GPI-anchored and as a transmembrane form each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells